How P&G avoids animal testing

From ANIMAL PEOPLE, November 2004:

Replacement Method

Cytosensor microphysiometer method
Ex vivo rabbit enucleated eye irritation test
Bovine ex vivo corneal opacification permeability test
Chicken ex vivo enucleated eye irritation test
In vitro matrix corrosivity assay (Corrositex) *
Eye human tissue equivalence assay (EpiOcular) *
Eye in silico structure/activity relationship model
Skin human tissue equivalence assay (EpiDerm) *
Skin human tissue equivalence assay (EpiDerm + MTT, IL-1)
In vitro skin penetration assay *
In silico skin penetration SAR model
Proportionality (calculation) method for acute toxicity *
In vitro tissue equivalence assay for gastric irritation
Peptide reactivity screening assay
Skin allergy genomic assay
In silico sensitization SAR model
In vitro guinea pig antibody assay for Type I anaphylaxis
In silico SAR, coupled with in vitro peptide binding
Estrogen receptor competitive binding assay
Androgen receptor competitive binding assay

Estrogen transcriptional activation assay
Chick embryonic retinal cell assay
Ames mutagenicity assay *
In vitro chromosomal aberration assay *
In vitro micronucleus assay *
SHE cell transformation assay *
Chemical assay for hyaline droplet induction
In silico genetox SAR model
In vitro fish toxicity assay

Reduction Method

Up-down procedure *
Limit dose method *
Fixed-dose method *
Acute-toxic-class procedure *
Low-volume eye test *
Murine local lymph node assay *
Murine intranasal allergenicity test
Rodent whole embryo culture assay
Tg.AC transgenic mouse model *
P53+/- TS gene knockout mouse model *
In vivo chromosomal aberration assay *
In vivo unscheduled DNA synthesis (in vivo UDS) assay *

* Has at least partial regulatory acceptance

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